Author

A. M. K. El-sagheir

2 papers indexed here

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Editorial Sep 2026

From Undruggable to Actionable: Redefining Druggability Through Emerging Therapeutic Modalities.

The concept of "undruggable" targets has long represented a major limitation in medicinal chemistry, referring to proteins and biomolecules that lack well-defined binding pockets or exhibit highly dynamic conformational behavior. However, advances in structural biology, chemical biology, and computational methodologies...

A. M. K. El-sagheir · ChemMedChem · 0 citations

Review Open access Sep 2026

Artificial intelligence-assisted lead optimization in drug discovery: bridging computational advances and translational challenges.

It is concluded that future progress will depend less on increasingly sophisticated algorithms than on trustworthy AI systems that improve scientific decision-making within iterative lead optimization workflows and ultimately enhance translational success in drug discovery.

F. A. Mohamed, A. M. K. El-sagheir · Medicinal Chemistry Research · 0 citations