Open access
Sep 2026
Substrate Profiling of RNF216 Uncovers a Translation-Linked OTUD4 Regulatory Axis
Overall, the findings show that RNF216 and OTUD4 balance rates of protein synthesis and degradation and suggest GHS-related mutations in RNF216 or OTUD4 may offset this balance, triggering neurodegeneration.
Wei Wei, Ruochuan Liu, Jing Zhang et al.
· bioRxiv · 0 citations