Open access
Aug 2026
Comprehensive transcriptomic profiling reveals impaired polyamine metabolism as a contributor to age-related muscle decline
A spatial transcriptomic atlas of skeletal muscle from young and aged mice is presented, resolving transcriptional reprogramming across fiber types and tissue compartments and revealing alterations in sarcomeric organization, excitation-contraction coupling, oxidative stress responses, and fiber type-specific metabolic rewiring.
Veronica Ruggieri, Andrea Bracaglia, Lorenza Esposito et al.
· iScience · 0 citations