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Sep 2026

Multiscale temporal tuning of the force generation complex governs cortical microtubule interactions during the first mitotic division in C. elegans.

Dynein is an essential microtubule motor whose many roles in mitosis complicate efforts to resolve its spatiotemporally dynamic regulation. We previously established a method to classify single particles of the conserved cortical force generation complex (dynein-LIN-5NuMA-GPR-1/2LGN-GαGαi), as free or interacting with...

G. A. Edwards, John B. Linehan, A. Maddox et al. · 0 citations
Open access Aug 2026

Apoptosis promotes fertility in Caenorhabditis elegans by maintaining functional germline morphology

ABSTRACT Programmed cell death (apoptosis) during oogenesis is conserved across metazoans and linked to regulation of oocyte number and quality. In oogenic germlines, the removal of developing oocytes by apoptosis ensures that oocytes do not contain DNA damage or multiple nuclei. Beyond this chromatin-quality control a...

Udodirim N. Saydee-Onwubiko, Michael E. Werner, Gavin C. Trapp et al. · 1 citation

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