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Open access Aug 2026

Tolerability, dose modification, and treatment compliance with adjuvant abemaciclib in high-risk early breast cancer: a UK real-world multicentre study (CONCISE)

Background Abemaciclib plus endocrine therapy improves outcomes in high-risk hormone receptor-positive, HER2-negative early breast cancer (EBC) in monarchE, but real-world tolerability, dose modification, and treatment persistence in routine UK practice remain incompletely characterised. Patients and methods A retrospe...

H. Abdallah, Y. Owoseni, B. Baraka et al. · 0 citations
Review Open access Aug 2026

IUC26658-92 Efficacy Patterns of First-Line Immune Checkpoint Inhibitor Combinations in Metastatic Clear Cell Renal Cell Carcinoma: A Systematic Review and Meta-Analysis Evaluating Ethnic Variations

Abstract Background First-line immune checkpoint inhibitor (ICI)-based combinations have transformed metastatic renal cell carcinoma (mRCC) outcomes. However, the influence of patient ethnicity remains poorly characterized due to historical underreporting in major clinical trials. This study performed an ethnicity-base...

D. Khanna, T. Dey, E. Blanchard-Cavagis et al. · 0 citations

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