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Author

A. Manninen

2 papers indexed here

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Open access Oct 2026

A Germline-Encoded lncRNA-Mitochondrial Axis Rewires Oxidative Phosphorylation to Drive Progression in Clear Cell Renal Cell Carcinoma.

Clear cell renal cell carcinoma (ccRCC) is characterized by profound metabolic reprogramming and substantial inherited susceptibility. The molecular mechanisms linking germline risk variation to tumor metabolic reprogramming could potentially be exploited for precision interventions. Here, we aimed to delineate the ger...

Guo-Wen Duan, Wen-Jie Xu, Wen-Jun Jiang et al. · 0 citations
Open access Sep 2026

β4-integrins safeguard nuclear mechanics to suppress prostate cancer progression

Prostate cancer (PCa) progression is accompanied by profound alterations in cell-extracellular matrix (ECM) adhesion, nuclear architecture and mechanical adaptability, yet the molecular mechanisms linking these processes remain poorly understood. Hemidesmosomes (HDs), formed by α6β4-integrins, anchor epithelial cells t...

Anette Schmidt, Rong Wei, Paulina Nastały et al. · 0 citations

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