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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

A. Markov

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Sep 2026

N-(3'-(Dimethylamino)propyl)amides based on 18βH-glycyrrhetinic acid retain P-glycoprotein inhibitory and MDR-reversing activities.

Multidrug resistance (MDR) is a major obstacle to successful cancer chemotherapy, primarily mediated by P-glycoprotein (P-gp/ABCB1), which actively effluxes structurally unrelated anticancer drugs. We previously reported Sol-DMAP, an 18βH-glycyrrhetinic acid-derived P-gp inhibitor that reverses chemoresistance and exhi...

A. Moralev, Nika V. Konoreva, O. Salomatina et al. · 0 citations

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