Author

A. Merlino

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Open access Jul 2026

Unveiling the molecular basis of Pleurocybella porrigens lectin (PPL)-glycan recognition by NMR and X-ray crystallography.

The structural basis of Gal/GalNAc selectivity in PPL is clarified and the broader utility of ricin-B-like lectins as probes for biologically and clinically relevant O-glycan epitopes is supported, highlighting the complementarity of NMR and X-ray crystallography for the integrated characterization of lectin-glycan int...

Angela Marseglia, Gabriella Tito, G. Ferraro et al. · International Journal of Bio... · 0 citations

Open access Aug 2026

Protein Recognition and Amyloid Remodeling Governed by Paddlewheel Diruthenium Coordination Chemistry

Paddlewheel diruthenium (Ru2) complexes are promising modulators of protein aggregation due to their tunable coordination chemistry and dual-action properties. Here, we investigate the interaction of five Ru2 complexes with hen egg white lysozyme (HEWL), an amyloid model, to elucidate their antiaggregation capabilities...

S. La Manna, Daniele Florio, G. Ferraro et al. · Inorganic Chemistry · 0 citations

Open access Jul 2026

Thioredoxin Reductase as a Target for Antibacterial Gold Compounds in Burkholderia cenocepacia: Disclosing the Molecular Basis of Enzyme Inhibition

Thioredoxin reductase from Burkholderia cenocepacia (Bc‐TrxR) is a recognized intracellular target of antibacterial gold(I) compounds, yet the molecular basis of enzyme inhibition remains unclear. Here, we report an integrated structural, biophysical, and biochemical investigation of recombinant Bc‐TrxR and its interac...

Stefano Zineddu, José Aleixo de Azevedo-França, Martina Aguanno et al. · ChemBioChem · 0 citations