Importance
Idiopathic normal pressure hydrocephalus (iNPH) is a progressive neurological disorder characterized by cerebral ventricular enlargement that is typically associated with gait impairment and often urinary dysfunction and cognitive decline in older adults. iNPH prevalence is approximately 1% to 4% among indiv...
S. Maroufi, Sevil Yasar, A. Moghekar et al.· Journal of the American Medi...· 2 citations
Objective: Plasma concentrations of amyloid-beta 42/40 (Aβ42/40) and phosphorylated tau 217 (p-tau217) are now routinely ordered clinically in older adults as proxy markers for brain Aβ pathology in Alzheimer’s disease. Marked kidney impairment in chronic kidney disease (CKD) influences Aβ42/40 and p-tau217 measureme...
Alejandra Woolsey, Jennifer M. Coughlin, Katelyn R. Jenkins et al.· Archives of Clinical Neurops...· 0 citations
Objectives: Developing sensitive imaging biomarkers is critical for capturing early brain alterations in Alzheimer’s disease. This exploratory study aimed to evaluate how multiparametric magnetic resonance imaging (MRI) measures, including chemical exchange saturation transfer (CEST) imaging, can detect early cognitive...
Zong-Pai Zhang, Jing-Pu Wu, Isabel M. Rios Pulgar et al.· Neurology International· 0 citations
Introduction Daily patterns of activity, rest, and sleep, referred to as rest–activity rhythms (RARs), can be characterized by their day-to-day regularity, within-day fragmentation, and contrast between active and rest periods across the 24-h cycle. Disruptions (e.g., irregular schedules, fragmented activity, or reduce...
Daniel D. Callow, Nisha Rani, A. Spira et al.· Frontiers in Aging Neuroscie...· 0 citations
Vascular cognitive impairment and dementia (VCID) is a common cause of cognitive impairment, yet validated biomarkers, particularly those reflecting vascular function, remain lacking. Oxygen extraction fraction (OEF), which reflects the functional status of cerebral small vessels, is a potential physiological biomarker...
Jie Song, Wen Shi, Julia Suconic et al.· Alzheimer's & Dementia· 0 citations
Higher levels of peripheral pro-inflammatory markers are associated with white matter microstructure associated with multi-shell dMRI Neurite Orientation Dispersion and Density Imaging (NODDI), supporting the sensitivity of these dMRI-based metrics to inflammatory processes.
Siona Mishra, C. Pettigrew, Chidi Ugonna et al.· Neurobiology of Aging· 0 citations
BACKGROUND
Demonstrating the specificity of plasma biomarkers to AD-related neurodegeneration would add support to their prognostic and diagnostic clinical use.
METHOD
Participants from the Baltimore Longitudinal Study of Aging were cognitively unimpaired at the time of their plasma Aβ42/Aβ40, GFAP, NfL (Quanterix Ne...
Murat Bilgel, Ishaan Shah, Jasmine M. Cooper et al.· Alzheimer's & Dementia· 0 citations
Among CU individuals, plasma p-tau217 was associated with subsequent MCI/dementia due to AD and showed the most extensive associations with longitudinal AD-related brain atrophy, compared with SPARE-BA or R-indices capturing subcortical, diffuse cortical, or perisylvian atrophy.
Murat Bilgel, Ishaan Shah, Jasmine M. Cooper et al.· medRxiv· 0 citations
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