Delicate Balance of Intra- and Inter-Molecular Entropic Effects in S-S Peptide Cyclization.
Cyclic peptides with intramolecular S-S bonds are an important segment of the pharmaceutical market and are actively investigated as drug candidates for cancer, orphan, and autoimmune diseases. The disulfide bond-forming step often dictates the yield and purity of these peptides, yet its molecular mechanism in iodine-m...