Open access
Oct 2026
Repeated cocaine exposure and prolonged withdrawal drive morphological and molecular remodeling of hippocampal microglia in response to acute stress.
Repeated cocaine exposure during adolescence disrupts physiological brain maturation, inducing persistent neuroplastic adaptations that evolve throughout withdrawal. Because stressful experiences are among the most powerful triggers of relapse during abstinence, uncovering how cocaine withdrawal affects the neurobiolog...
F. Mottarlini, P. Miglioranza, Emile Etienne Zweistra et al.
· Pharmacological Research · 0 citations