Defining and operationalizing negative symptom constructs in schizophrenia: A practical guide for clinicians, researchers, and industry stakeholders.
Negative symptoms (NS) are a core dimension of schizophrenia and a major determinant of real-life functioning. The National Institute of Mental Health-Measurement and Treatment Research to Improve Cognition in Schizophrenia (NIMH-MATRICS) initiative and the European Psychiatric Association (EPA) guidance have refined N...