Author

A. Muotri

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Open access Aug 2026

Corticothalamic assembloids recapitulate human fetal brain morphologies and enhance neuronal complexity.

This work makes an initial effort in describing the diversity of neuronal morphology in human neural organoids and assembloids, and establishes structural phenotyping as a critical dimension for validating human neural models and underscores their value for modeling morphofunctional disorders.

André Saraiva Leão Marcelo Antunes, Maria Carolina Pedro Athié, Ana C. Caznok Silveira et al. · Neuroscience · 1 citation

Aug 2026

Human Brain Organoid-Enabling Discoveries Reach the Clinic: A Translational Inflection Point.

Two cases in which organoid-derived findings enabled FDA-approved clinical trials are highlighted, illustrating how organoids can reveal disease mechanisms that are inaccessible or incompletely reproduced in animal models.

A. A. Martins, A. Muotri · Stem Cells and Development · 0 citations