A narrative review explores how platelet activation may contribute to MS through blood-brain barrier dysfunction, immune-cell recruitment, oxidative stress, demyelination, and neurodegeneration, and critically examines acetylsalicylic acid (ASA) as a potential platelet-targeted strategy.
H. Al-Jehani, Hayder M. Al-kuraishy, Weam A. Elkady et al.· Multiple Sclerosis and Relat...· 0 citations
PAF/PAF-R targeting remains a mechanistically promising but clinically unestablished therapeutic approach requiring further translational investigation, and some detrimental effects of PAF appear to occur independently of PAF-R.
A. Baothman, Hayder M. Al-kuraishy, Weam A. Elkady et al.· Multiple Sclerosis and Relat...· 0 citations
2ANN is identified as a promising AMP candidate for further investigation against MDR P. aeruginosa, as the findings are based exclusively on computational prediction and simulation, experimental validation is required to confirm its biological activity and mechanism of action.
D. G. T. Parambi, P. Prabitha, T. Alsahli et al.· Probiotics and Antimicrobial...· 0 citations
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