Transcriptomic profiling of skeletal muscle in nNOS-deficient mice implies nitrate-induced activation of muscle development pathways
Nitric oxide (NO), a potent vasodilating agent, plays an essential role in regulation of mitochondrial respiration, and is crucial for proper skeletal muscle function. In skeletal muscle, neuronal NO synthase (nNOS) produces NO and regulates the nitrate/nitrite reductive pathway. nNOS is anchored to the sarcolemm...