Open access
Aug 2026
Cholesterol Dysregulation in APOE4 Astrocytes Promotes α-Synuclein Pathology in miBrains
An iPSC-based 3D model that integrates neurons, glia, myelin, and cerebrovascular cells into a human brain-like tissue (“miBrain”) is developed and establishes a robust model for investigating protein inclusions in human iPSC-derived brain tissue.
Louise A. Mesentier-Louro, Camille Goldman, Sebastian Gaese et al.
· Cell Stem Cell · 2 citations