Open access
Aug 2026
Lysyl oxidase inhibition disrupts mitochondrial homeostasis to create vulnerability to ferroptosis in TNBC
The “one-two punch” approach combining LOX inhibition with clinical DHODH inhibitor suppresses tumor growth in vivo in chemo-free setting and shows that inhibiting LOX generates targetable vulnerability to ferroptosis.
O. Saatci, B. Ulukan, Metin Cetin et al.
· Cell Reports Medicine · 1 citation