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A. Nichols

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Open access Oct 2026

Neoadjuvant PIK3CA Inhibition With Alpelisib in Head and Neck Squamous Cell Cancer: A Window-of-Opportunity Trial and Biomarker Study

PIK3CA -activating mutations and amplifications are common in both human papillomavirus (HPV)–positive and HPV-negative head and neck squamous cell carcinomas (HNSCCs). PI3K pathway inhibition is postulated as a potential therapeutic strategy, and preclinical studies have demonstrated that the PI3Kα selective in...

A. Nichols, Peter Y. F. Zeng, M. Cecchini et al. · 0 citations

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