Design, synthesis, and biological evaluation of isatin-based benzenesulfonamides as carbonic anhydrase II/VII inhibitors with anticonvulsant activity.
Epilepsy remains a challenging neurological disorder, with a significant proportion of patients exhibiting resistance to current antiseizure medications. Herein, we report the rational design, synthesis, and biological evaluation of a new series of isatin-thiazolidine-2,4-dione hybrids bearing a pendant benzenesulfonam...