A. Nore

Mammalian condensin I controls higher-order chromosome organization and homologous recombination in meiotic prophase I

The meiotic chromosome structure, defined by the axis-chromatin loop organization, is essential for proper homologue synapsis through the formation of the synaptonemal complex, and faithful homologous recombination. Here, we show that the conserved SMC-condensin I complex, which shapes the genome through chromatin loop...