Open access
Sep 2026
AI-guided epitope engineering of a SARS-CoV-2 spike antigen for broad sarbecovirus neutralization
These findings show that minimal, structure-guided epitope remodeling can enhance the presentation of conserved epitopes and improve antibody breadth, providing a generalizable framework for designing vaccines resilient to viral evolution and future pandemic threats.
A. Odainic, Ioannis Vardaxis, M. Ferraz et al.
· Frontiers in Immunology · 0 citations