Neutrophil Reprogramming Fuels Immunosuppression in Staphylococcus aureus Biofilm Infection 2256977
This findings reveal that S. aureus biofilms exploit TLR2-MyD88 signaling to reprogram neutrophils into immunosuppressive G-MDSC-like cells, which highlights both bacterial-derived TLR2 ligands and host TLR2 signaling as promising therapeutic targets to restore antimicrobial immunity in neurosurgical infections.