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Author

A. O'Neill

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Open access Aug 2026

Enforcing mTORC1 activity in therapeutic CD4+ T cells promotes persistence but eventual immune exhaustion.

The dynamic population response to tuning of T cell mTORC1 and the need to separately appraise cellular outputs of therapeutic CD4+ versus CD8+ T cells when metabolic pathways are manipulated by the same method are demonstrated.

F. Sillito, Elisa Armbrecht, A. O'Neill et al. · 0 citations

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