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A. Onyango

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Review Oct 2026

Mechanisms of Hepatic Insulin Resistance and Its Contribution to the Pathogenesis of Type 2 Diabetes

In hepatocytes, the main parenchymal liver cells, insulin binding to its receptor leads to activation of protein kinase B (AKT), which stimulates glycogen synthesis and lipogenesis but inhibits glucose production (glycogenolysis and gluconeogenesis). Hepatic insulin resistance (HIR) is expected to increase glucose prod...

A. Onyango · 0 citations

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