Open access
Sep 2026
Increased mtDNA Polymorphism Level and Defective Mitophagy are Associated With Proinflammatory Activation in THP-1-Based Cybrids.
BACKGROUND Mitochondria play a key role in the regulation of inflammatory processes. It is well established that mitochondria contain their own mitochondrial DNA (mtDNA), which displays a substantially higher frequency of polymorphisms compared to the nuclear genome. To maintain mitochondrial functionality, cells emplo...
A. D. Zhuravlev, N. Nikiforov, S. Verkhova et al.
· Frontiers in Bioscience · 0 citations