A. P. Karlapudi

Structure-based identification of a membrane-retained OmpA candidate against Acinetobacter baumannii by membrane molecular dynamics and phenotypic antibacterial assessment.

Outer membrane protein A (OmpA) contributes to the envelope integrity and virulence of Acinetobacter baumannii and contains a lumenal cavity that may accommodate small molecules. We screened 99,878 ChEMBL-derived compounds against a structural model of the OmpA transmembrane barrel using two rounds of docking followed...

Partial purification and characterisation of an Enterocin P-like bacteriocin from Enterococcus faecium E18

Integrative Single-Cell, Spatial, and Bulk Transcriptomics Characterizes an Outcome-Associated, Spatially Organized Mesenchymal Program in IDH-Mutant Glioma

A mesenchymal gene-expression program linked to inflammation and tissue remodeling was consistently associated with higher tumor grade and shorter survival, and within tumor tissue it was clearly organized in space.