A. P. Morris

Genetic Architecture and Sample Size Impact Relative Performance of Nonlinear Machine Learning and Standard Polygenic Risk Scores

Standard polygenic risk scores (PRSs) are constructed based on additive genome-wide association study (GWAS) summary statistics. Nonlinear machine learning methods have been increasingly applied to construct PRSs directly from individual-level data, with the aim of improving predictive performance over standard PRSs th...