Á. Pacheco-Silva

Butyrate improves the metabolism of proximal tubular cells and attenuates tissue damage in oxalate-induced acute kidney injury.

Metabolic reprogramming of renal cells is closely linked to kidney injury and repair. In proximal tubular cells (PTCs), impaired mitochondrial and peroxisomal fatty acid oxidation leads to compensatory increase in glycolysis to meet energy demands. Short-chain fatty acids such as butyrate modulate cell metabolism and c...