L-serine-enriched diet restores impaired adult neurogenesis in the hippocampus of 3xTg-AD mice.
BackgroundAltered adult neurogenesis occurs in Alzheimer's disease (AD) in humans and rodent models, though the mechanisms remain unclear. L-serine, a non-essential amino acid critical for cell proliferation and survival, is produced by neuroepithelial cells and radial glia in the developing brain, and by astrocytes an...