Mitochondria transfer via tunneling nanotubes drives macrophage immunosuppression and metabolic reprogramming in pediatric AML.
It is demonstrated that immunosuppressive macrophages dominate the AML microenvironment and support growth of RUNX1::RUNX1T1 and KMT2A-rearranged leukemic blasts and suggested that targeting AML-macrophage interactions could enhance the efficacy of T cell-based immunotherapies.