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A. Poetsch

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Open access Sep 2026

A pancreatic cancer organoid-macrophage co-culture using starPEG-heparin hydrogel deciphers tumor-immune cell interactions

Macrophages are among the most abundant immune cells in the pancreatic ductal adenocarcinoma (PDAC) tumor microenvironment (TME) and play a key role in regulating the immunosuppressive niche that facilitates tumor growth. Although recent three-dimensional (3D) culture systems using patient-derived materials have advanc...

Julius Thyen, V. A. Sioson, Daniel Haak et al. · 0 citations
Open access Aug 2026

Nup153 regulates neuronal responsiveness through HDAC1-mediated epigenetic modulation

Nucleoporin-dependent regulation of neuronal responsiveness is identified, in which Nup153 represses neuronal genes including activity-regulated genes (ARGs), in the basal state, by characterizing the genome-wide landscape of chromatin accessibility, histone modifications and Nup153 chromatin binding.

Abhinav Soni, S. Petridi, Maria Ludovica Sforza et al. · 0 citations
Jul 2026

Using Deep Learning to predict replication timing reveals baseline control of genomic DNA sequence

The relationship between DNA sequence and the epigenome relative to RT is dissect and it is suggested that primary DNA sequence instructions exert a powerful baseline control over constitutive and cell-type-specific RT, fine-tuned by regulatory cues beyond the DNA sequence.

Nikola Janakievski, Pierre M. Joubert, A. Poetsch · 1 citation

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