Macrophages are among the most abundant immune cells in the pancreatic ductal adenocarcinoma (PDAC) tumor microenvironment (TME) and play a key role in regulating the immunosuppressive niche that facilitates tumor growth. Although recent three-dimensional (3D) culture systems using patient-derived materials have advanc...
Julius Thyen, V. A. Sioson, Daniel Haak et al.· npj Precision Oncology· 0 citations
Nucleoporin-dependent regulation of neuronal responsiveness is identified, in which Nup153 represses neuronal genes including activity-regulated genes (ARGs), in the basal state, by characterizing the genome-wide landscape of chromatin accessibility, histone modifications and Nup153 chromatin binding.
Abhinav Soni, S. Petridi, Maria Ludovica Sforza et al.· bioRxiv· 0 citations
The relationship between DNA sequence and the epigenome relative to RT is dissect and it is suggested that primary DNA sequence instructions exert a powerful baseline control over constitutive and cell-type-specific RT, fine-tuned by regulatory cues beyond the DNA sequence.
Nikola Janakievski, Pierre M. Joubert, A. Poetsch· bioRxiv· 1 citation
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