Author

A. Polissi

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Open access Sep 2026

Time-resolved transcriptomic analysis reveals envelope stress–mediated adaptation of Escherichia coli to the LPS transport inhibitor thanatin

Gram-negative bacteria are a major cause of antibiotic-resistant infections due to their highly impermeable cell envelope which contains lipopolysaccharide (LPS) and prevents antibiotics from entering the cell. LPS biogenesis relies on the activity of the essential LPS transport machinery (Lpt), which represents an att...

R. Bisht, Elisabete C. C. M. Moura, Julien Prados et al. · Frontiers in Microbiology · 0 citations

Review Open access Aug 2026

Peptidoglycan Remodeling in Gram-Negative Bacteria: From Stress Adaptation to Antibiotic Tolerance and Therapeutic Targeting

The peptidoglycan (PG) sacculus of Gram-negative bacteria is continuously reorganized by a diverse enzymatic repertoire, including lytic transglycosylases, endopeptidases, carboxypeptidases, amidases and LD-transpeptidases, that operate alongside PG synthases to maintain envelope integrity throughout the cell cycle. Th...

Theresa Strohhammer, A. Martorana, A. Polissi · Antibiotics · 0 citations