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Author

A. Prudova

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2 papers indexed here

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Open access Sep 2026

Degradomic and Transcriptomic Profiling Reveals Pleiotropic Roles of Extracellular Granzyme B in Scarring and Fibrosis.

Granzyme B (GzmB) is a serine protease traditionally recognized for its role in lymphocyte-mediated apoptosis. In specific conditions, GzmB accumulates in the extracellular milieu and retains its proteolytic activity, cleaving extracellular proteins thereby contributing to disease progression. Nevertheless, pathologica...

A. Aubert, A. Prudova, Jeffrey S. Tang et al. · 0 citations
Open access Sep 2026

Extracellular granzyme K links inflammatory signaling to nucleotide metabolism, driving epithelial hyperproliferation and reprogramming

Granzymes (Gzms) are a family of serine proteases that have been traditionally studied as cytotoxic mediators of lymphocyte-mediated target cell death. However, increasing evidence suggests that during inflammation Gzms can accumulate in the extracellular milieu and contribute to various pathologies depending on the...

K. Richardson, Jeffrey S. Tang, A. Aubert et al. · 0 citations

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