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Author

A. R. Costa

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Open access Sep 2026

Distinct Arp2/3 isocomplexes drive axonal actin ring assembly and integrity

The actin-related protein 2/3 (Arp2/3) complex is a central nucleator of branched actin filaments, essential for numerous cellular processes. Using superresolution imaging, we demonstrate that Arp2/3 is a component of the membrane periodic skeleton (MPS)—a highly ordered actin ring-spectrin lattice in the submembrane a...

A. R. Costa, Teresa Lopes, Luís P. Rodrigues et al. · 0 citations
Review Open access Jul 2026

Curving Actin Across Systems: Do Axonal Actin Rings Share Common Underlying Mechanisms?

Actin polymerization into curved and ring‐shaped structures is an evolutionarily conserved mechanism that cells use to generate force, transmit tension, and maintain membrane architecture. In neurons, super‐resolution imaging has revealed a striking periodic submembranous scaffold in axons, composed of circumferential...

A. R. Costa, Luís P. Rodrigues, Monica M. Sousa · 0 citations

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