Open access
Sep 2026
Helicase-deficient TFIIH causes severe disease features via persistent DNA excision without damage removal
It is demonstrated that NER incisions can occur without XPD-mediated damage verification and that persistent futile DNA excision cycles cause severe disease features, indicating that persistent NER intermediates are more pathogenic than unrepaired DNA lesions.
David Häckes, A. Theil, Geunhee Kim et al.
· bioRxiv · 0 citations