B-cell modulators in immunoglobulin A nephropathy
Immunoglobulin A nephropathy (IgAN), defined by mesangial immune-complex deposition enriched for galactose-deficient IgA1 (Gd-IgA1), is the most prevalent biopsy-confirmed primary glomerulonephritis worldwide. Advances in mucosal immunobiology and genetics have underscored the role of dysregulated B-cell activity, incr...