Review
Open access
Jul 2026
Targeting Tumour Heterogeneity through sequential timing of anti-hallmark combination therapies -a hypothesis for implementation
By reverting mesenchymal phenotypes and normalizing the vasculature, the CTS protocol is designed to rescue the immune-suppressive tumor microenvironment and restores cytotoxic T-cell homing, thereby converting immunologically “cold” tumors into “hot,” immunotherapy-responsive lesions.
Kumara Swamy, Guruaj Arakeri, Ramaswamy Veena et al.
· Frontiers in Immunology · 0 citations