BRCA1 and HRR pathway genes in triple-negative breast cancer patients: clinical outcomes in an admixed Brazilian cohort
Triple-negative breast cancer (TNBC) is an aggressive and heterogeneous subtype of breast cancer, frequently associated with early-onset disease, hereditary susceptibility and African ancestry. A substantial proportion of TNBC cases are linked to germline pathogenic variants (gPVs) in BRCA1 , a key gene in th...