Time-resolved transcriptomic analysis reveals envelope stress–mediated adaptation of Escherichia coli to the LPS transport inhibitor thanatin
Gram-negative bacteria are a major cause of antibiotic-resistant infections due to their highly impermeable cell envelope which contains lipopolysaccharide (LPS) and prevents antibiotics from entering the cell. LPS biogenesis relies on the activity of the essential LPS transport machinery (Lpt), which represents an att...