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Author

A. Rose

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Open access Aug 2026

RAF/MEK clamp inhibition with avutometinib and cetuximab in RAF1 S257L–mutated, anti-EGFR–refractory metastatic colorectal cancer in Gaucher’s disease

Abstract RAF1 alterations are rare in metastatic colorectal cancer (mCRC), occurring in roughly 0.5% of cases, and lack established treatment guidance. We present a patient with RAF1 S257L–mutated, RAS wild-type mCRC and concurrent type 1 Gaucher disease, whose baseline cytopenias precluded standard chemotherapy and cl...

A. Rose, Alix Rosenberg, U. Grewal et al. · 0 citations
Open access Aug 2026

Age-stratified mutation patterns in early-onset colorectal cancer reveal distinct molecular features and therapeutic implications

Differences in mutations of key genes including a lower prevalence of APC mutations and increased SMAD4 mutations in younger individuals provides further supporting evidence that early-onset CRC may represent a distinct biological subtype of CRC.

L. Liu, A. Rose, A. Samaddar et al. · 0 citations

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