Author

A. Růžička

2 papers indexed here

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Open access Oct 2026

Substituted diiminoisoindoles as anticancer agents: synthesis, structural characterization, and biological evaluation.

Substituted diiminoisoindoles (DIIs), 1- 20, were synthesized as a nitrogen-rich scaffolds for evaluation of their anticancer activity. A streamlined one-pot lithiation/isoindole formation strategy enabled the preparation of a broad portfolio of dissymmetrically substituted DIIs from substituted anilines and dicarbonit...

Stanislava Majerová, Otakar Pojmon, Filip Verunáč et al. · Bioorganic chemistry (Print) · 0 citations

Open access Aug 2026

Uncover the strength of polyhedral dicarbaboranes as the next generation of superbases in organocatalysis

Although boron compounds appear in many chemical transformations, it is hard to imagine, these usually Lewis acidic, species would act as Lewis bases or even base-catalysts. Here we show that the adduct o-2, formed by the reaction of closo−1,2-dicarbadecaborane(10) with two equivalents of an N-heterocyclic carbene, exh...

Jan Vrána, Zuzana Kapustová, M. Kamlar et al. · Nature Communications · 0 citations