Author

A. S. Bakman

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Aug 2026

Activity of natural single nucleotide variants of human alkyladenine DNA glycosylase AAG R145H, G163S and R197C involved in DNA binding.

Alkyladenine DNA glycosylase (AAG) is a critical enzyme in the base excision repair (BER) pathway that safeguards genome integrity by removing structurally diverse alkylated and deaminated purine lesions from DNA. It serves as a primary defense against alkylation-induced mutations, which are linked to cancer developmen...

O. A. Kladova, T. E. Tyugashev, A. Miroshnikov et al. · Biochimica et Biophysica Act... · 0 citations

Open access Jul 2026

Substrate-Specific Inactivation of Human AAG by Tumor-Associated Single Nucleotide Polymorphic Variants

It is demonstrated that non-active-site SNPs can qualitatively reprogram the substrate specificity of AAG, and could be considered as potential functional biomarkers for cancer risk and response to alkylating chemotherapy.

O. A. Kladova, T. E. Tyugashev, A. S. Bakman et al. · International Journal of Mol... · 0 citations