Open access
Sep 2026
Artificial intelligence modeling of small molecule pharmaceutical solubility in supercritical fluid and comparative analysis under temperature and pressure variations
Enhancing the dissolution behavior of poorly water-soluble pharmaceuticals remains an important challenge in drug formulation and manufacturing, since limited aqueous solubility can substantially restrict therapeutic performance. Supercritical-fluid technologies provide a promising route for addressing this limitation,...
Hao-Lin Wu, Hadil Faris Alotaibi, A. S. Fahem et al.
· Frontiers in Chemistry · 0 citations