Author

A. S. Yatsenko

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Open access Aug 2026

A conserved serotonin receptor pathway is a druggable modifier of Tau pathology, neural circuit formation and neurodegeneration

A new Drosophila tauopathy model expressing eGFP-tagged human TauWT or the disease-associated TauP301L variant in the nervous system is established and 5-HT7R signaling is identified as a conserved and druggable modifier of Tau toxicity.

Mariana I. Tsap, Valeriya V. Navrotska, J. Labus et al. · bioRxiv · 0 citations