It is reported that p38α deficiency attenuates ferroptosis and protects against myocardial I/R injury by stabilizing c-Myc, and the p38α/c-Myc/NCOA4 axis is nominated as a potential therapeutic target in myocardial I/R injury.
Xiao-Hu S. Ouyang, Shu-Xin Song, Ya-Lan Dong et al.· Basic Research in Cardiology· 0 citations
This work proposes a threshold management framework for DRE, built on a revised reservoir model, and translates it into three structural priorities: mechanistic phenotyping to stratify patients by pathophysiological domain, dual-mechanism drug development, and trial designs suited to multicomponent, context-dependent i...
Alexander Trofimov, Ksenia Shcherbakova, Alexander Schwarz et al.· International Journal of Mol...· 0 citations
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