Abstract INTRODUCTION Adherence to the Mediterranean–Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet is associated with reduced dementia risk, but underlying mechanisms remain unclear. METHODS Plasma proteomics (SomaScan 7k) from 206 Indiana Alzheimer's Disease Research Cent...
Shane Fernandez, Desarae A. Dempsey, Soumilee Chaudhuri et al.· Alzheimer's & Dementia· 0 citations
Abstract INTRODUCTION Cerebral amyloid angiopathy (CAA) is characterized by impaired vascular amyloid‐β clearance, distinct from Alzheimer's disease (AD), underscoring the need to clarify its molecular basis for predicting therapy‐related amyloid‐related imaging abnormalities. METHODS We analyzed post‐mortem brain prot...
Sang-Won Han, Young Ho Park, Jung-Min Pyun et al.· Alzheimer's & Dementia· 0 citations
This work model AD progression as a deviation from aging using longitudinal amyloid PET and a self-supervised trajectory-learning framework and reveals a shared early path that bifurcated into an aging branch and an AD-related branch.
GenFAR, a modular deep learning framework that learns general, clinically informed features from brain MRIs, is introduced, showing that using the learned feature representation can substantially increase the sample efficiency of secondary deep learning training tasks and models, as well as improve their accuracy.
V. Bashyam, G. Erus, Jun-Hao Wen et al.· 0 citations
These findings uncover protein signatures that reflect underlying AD biology and provide a foundation for stage-specific biomarkers and therapeutic targeting, with important implications for patient stratification and personalized intervention strategies.
Saima Rathore, E. Dammer, Anantharaman Shantaraman et al.· Molecular Neurodegeneration· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
