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The review proposes a six-stage framework linking intended use, measurement validity, model evaluation, comparative utility and monitored deployment, and places each capability on it, clarifying where methodological progress can accelerate discovery and where conventional clinical validation remains indispensable.
AIM Adverse childhood experiences (ACE) are associated with greater symptom severity and treatment resistance in major depressive disorder (MDD), but their effects vary markedly across individuals. Growth factor polygenic profiles may contribute to this differential susceptibility by influencing stress responsivity, ne...
Worse peripheral hearing was associated with poorer unadjusted gait performance in cognitively unimpaired adults and apparent sex differences did not reach the prespecified threshold.
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