Review
Open access
Jul 2026
Exploration peptide-GPCR specificity beyond homology and tertiary structure: computational insights into deorphanization and molecular mechanisms.
The application of the interaction determinant likelihood (IDL) framework to closely related GPCR paralogs demonstrates the emergence of distinct peptide specificities through limited, context-dependent residue substitutions, without significant alterations in overall receptor structure.
A. Shiraishi, H. Satake
· General and Comparative Endo... · 0 citations