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A. Sieradzan

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Open access Oct 2026

The AML-Associated A338V Mutation Rewires GPR183 Signaling through C-Terminal Ensemble Redistribution

G protein–coupled receptors (GPCRs) rely on dynamic conformational ensembles to coordinate G protein activation and recruitment of regulatory transducers such as GPCR kinases and β-arrestins. The oxysterol receptor GPR183 has been implicated in hematological malignancies, including acute myeloid leukemia (AML), where...

L. Andersson, P. Wesołowski, Laura Jahrstorfer et al. · 0 citations
Aug 2026

Understanding Fibroblast Growth Factor-Heparan Sulfate Recognition by Molecular Dynamics Approaches.

It is concluded that, depending on the 6-O-sulfation pattern and the length of the oligosaccharide, either predominantly electrostatic interactions or a more complex interplay between electrostatic and hydrophobic interactions determines the specificity of the resulting protein-glycosaminoglycan complex.

Sergey A. Samsonov, A. Sieradzan, Avner Yayon · 0 citations

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