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Author

A. Singanayagam

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Open access Sep 2026

Transmission-blocking vaccines for respiratory viruses: from concept to clinic

The obstacles to demonstrating transmission-blocking efficacy are outlined, from the absence of standardized correlates of protection to the limitations of animal and trial models, and how controlled human infection models, household studies, and field trials could help generate evidence to support regulatory engagemen...

A. Singanayagam · 0 citations
Open access Jul 2026

Biomarkers of protection against controlled human SARS-CoV-2 Delta variant breakthrough infection

Susceptibility to SARS-CoV-2 breakthrough infection in those with hybrid immunity is strongly associated with low levels of pre-existing antibody, but the diversity of immune markers associated with protection implies that additional benefits may be conferred by multi-pronged immunity.

A. Singanayagam, H. Wagstaffe, L. J. Slater et al. · 0 citations

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